ea0015oc13 | Reproduction | SFEBES2008
Harlow Christopher R
, Rae Michael
, Price Deborah
, McNeilly Alan S
, Rhind Stewart M
, Hillier Stephen G
The intraperitoneal environment of the ovarian surface epithelium (OSE) has an oxygen (O2) tension of 512%. This could impact cellular events leading to ovulation. Furthermore, ovarian cancers arising from the OSE (∼8090% of ovarian malignancies) are likely to experience increased hypoxia due to the relatively poor vascularisation of solid tumours.Using 1%, 5% or 20% O2, we measured the expression of HSD11B1, COX-2...